ALLERGEN NOMENCLATURE
WHO/IUIS Allergen Nomenclature Sub-Committee

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Allergen Details:

Allergen name: Can s 2
Lineage: Source: Plantae Magnoliopsida
Order: Rosales
Species: Cannabis sativa (Indian hemp)
Biochemical name:Profilin
MW(SDS-PAGE):14 kDa
Allergenicity:Five of 32 patients from Belgium and Germany (2) were positive in IgE binding tests with recombinant Can s 2 protein coupled to cytometric bead array. IgE were from 0.35 to 65 kUA/L among the 5. Routes of exposure were mostly inhalation though 2 cases it was ingestion, also all reported cutaneous reactivity to Cannabis. Multiple exposure routes.
Route of allergen exposure:Airway
Date Created:2021/01/24
Last Updated:2021-02-17 21:52:25
Submitter Info:
Name:Hans-Peter Rihs
Institution:IPA, Molecular Genetics
City:Bochum, Germany
Email:rihs@ipa-dguv.de
Submission Date:2020-11-27

Comments

Posted: 17 Feb 2021

Didier G. Ebo,Ine I. Decuyper,Hans-Peter Rihs,...Chris H. Bridts,Vito Sabato,Jessy Elst
Published online in JACIP: February 15, 2021 IgE-binding and mast cell activating capacity of the homologue of the major birch pollen allergen and profilin from Cannabis sativa.

Table of IsoAllergens Click +/- for additional information
Isoallergen and variants GenBank Nucleotide GenBank Protein UniProt PDB
Can s 2.0101XM030636604.1XP030492464.1