Allergen Details:
| Allergen name: | Can s 2 |
|---|---|
| Allergen source: |
Major taxonomic group: Plantae Eudikotyledons Order: Rosales Species: Cannabis sativa (Indian hemp) NCBI Taxomony ID: 3483 |
| Biochemical name: | Profilin |
| MW(SDS-PAGE): | 14 kDa |
| Allergenicity: | Five of 32 patients from Belgium and Germany (2) were positive in IgE binding tests with recombinant Can s 2 protein coupled to cytometric bead array. IgE were from 0.35 to 65 kUA/L among the 5. Routes of exposure were mostly inhalation though 2 cases it was ingestion, also all reported cutaneous reactivity to Cannabis. Multiple exposure routes. |
| Route of allergen exposure: | Airway |
| Date Created: | 2021/01/24 |
| Last Updated: | 2021-02-17 21:52:25 |
| Submitter Info: | |
| Name: | Hans-Peter Rihs |
| Institution: | IPA, Molecular Genetics |
| City: | Bochum, Germany |
| Email: | rihs@ipa-dguv.de |
| Submission Date: | 2020-11-27 |
Comments
| Isoallergen and variants | GenBank Nucleotide | GenBank Protein | UniProt | PDB |
|---|---|---|---|---|
| Can s 2.0101 | XM_030636604 | XP_030492464 |
Didier G. Ebo,Ine I. Decuyper,Hans-Peter Rihs,...Chris H. Bridts,Vito Sabato,Jessy Elst
Published online in JACIP: February 15, 2021 IgE-binding and mast cell activating capacity of the homologue of the major birch pollen allergen and profilin from Cannabis sativa.