ALLERGEN NOMENCLATURE
WHO/IUIS Allergen Nomenclature Sub-Committee

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Allergen Details:

Allergen name: Cap a 7
Lineage: Source: Plantae Magnoliopsida
Order: Solanales
Species: Capsicum annuum (Chili, bell pepper)
Obsolete name:Snakin
Biochemical name:Gibberellin-regulated protein
MW(SDS-PAGE):10 kDa reducing; 12 kDa non-reducing
Allergenicity:One Japanese of five well characterized consumers with two episodes of anaphylaxis to consumption of chili pepper, Capsicum annuum, was positive by SPT, basophil activation test and oral food challenge. The only protein recognized by patient’s IgE (via peptidic epitopes) was a GRP and IgE reactivity was inhibited by the recombinant protein. This patient's IgE also bound to GRP of Japanese cedar pollen, peach, citrus and potato.
Route of allergen exposure:Food
Date Created:2021/05/05
Last Updated:2021-05-06 18:22:57
Submitter Info:
Name:Pascal Poncet; Tomoyasu Aizawa
Institution:Institut Pasteur; Hokkaido University
City:Paris, France; Sapporo, Japan
Email:pascal.poncet@pasteur.fr; aizawa@sci.hokudai.ac.jp
Submission Date:2021-04-20

Comments

Posted: 05 May 2021

Note: This is a rare case of accepting IgE and BAT and SPT of well characterized allergy for one patient out of four potential allergic subjects. Normally we need to see IgE binding to at least 5 subjects, but in rare food allergy this can be over-ridden.

Table of IsoAllergens Click +/- for additional information
Isoallergen and variants GenBank Nucleotide GenBank Protein UniProt PDB
Cap a 7.0101