Allergen Details:
| Allergen name: | Cap a 7 |
|---|---|
| Allergen source: |
Major taxonomic group: Plantae Eudikotyledons Order: Solanales Species: Capsicum annuum (Chili, bell pepper) NCBI Taxomony ID: 4072 |
| Biochemical name: | Gibberellin-regulated protein, snakin |
| MW(SDS-PAGE): | 10 kDa reducing; 12 kDa non-reducing |
| Allergenicity: | One Japanese of five well characterized consumers with two episodes of anaphylaxis to consumption of chili pepper, Capsicum annuum, was positive by SPT, basophil activation test and oral food challenge. The only protein recognized by patient’s IgE (via peptidic epitopes) was a GRP and IgE reactivity was inhibited by the recombinant protein. This patient's IgE also bound to GRP of Japanese cedar pollen, peach, citrus and potato. |
| Allergenicity reference: | PubMed:35557497 |
| Route of allergen exposure: | Food |
| Date Created: | 2021/05/05 |
| Last Updated: | 2023-11-02 18:47:38 |
| Submitter Info: | |
| Name: | Pascal Poncet; Tomoyasu Aizawa |
| Institution: | Institut Pasteur; Hokkaido University |
| City: | Paris, France; Sapporo, Japan |
| Email: | pascal.poncet@pasteur.fr; aizawa@sci.hokudai.ac.jp |
| Submission Date: | 2021-04-20 |
Comments
| Isoallergen and variants | GenBank Nucleotide | GenBank Protein | UniProt | PDB |
|---|---|---|---|---|
| Cap a 7.0101 | XM_016697615 | XP_016553101 |
Note: This is a rare case of accepting IgE and BAT and SPT of well characterized allergy for one patient out of four potential allergic subjects. Normally we need to see IgE binding to at least 5 subjects, but in rare food allergy this can be over-ridden.