Allergen Details:
| Allergen name: | Hum j 6 |
|---|---|
| Allergen source: |
Major taxonomic group: Plantae Eudikotyledons Order: Rosales Species: Humulus japonicus (Japanese hop) NCBI Taxomony ID: 3485 |
| Biochemical name: | Pectin methylesterase inhibitor (PMEI; pectinesterase inhibitor) |
| MW(SDS-PAGE): | 10-15 kDa |
| Allergenicity: | Twenty-two patients with respiratory allergy who were sensitized to Japanese hop (specific IgE measured by ImmunoCAP) were tested. Of those, 19 (86%) had IgE to natural Hum j 6 purified from Humulus japonicus pollen as determined by ELISA. In contrast, recombinant allergens produced in E. coli Origami and Pichia pastoris bound only low amounts of IgE from 10 and 11 sera, respectively. The natural allergen is highly phosphorylated, but dephosphorylation did not affect IgE binding, as determined by immunoblot. |
| Route of allergen exposure: | Airway |
| Date Created: | |
| Last Updated: | 2022-06-14 18:01:14 |
| Submitter Info: | |
| Name: | Kyoung Yong Jeong, Jung-Won Park |
| Institution: | Yonsei University College of Medicine |
| City: | Seoul, Korea |
| Email: | jeongky@yuhs.ac, parkjw@yuhs.ac |
| Submission Date: | 2022-05-04 |
Comments
| Isoallergen and variants | GenBank Nucleotide | GenBank Protein | UniProt | PDB |
|---|---|---|---|---|
| Hum j 6.0101 | ON399181 |