Allergen Details:
| Allergen name: | Pla a 5 |
|---|---|
| Allergen source: |
Major taxonomic group: Plantae basal Mesangiosperms Order: Proteales Species: Platanus acerifolia (London plane tree) NCBI Taxomony ID: 140101 |
| Biochemical name: | Adenosylhomocysteinase (S-adenosyl-L-homocysteine hydrolase, AHCY) |
| MW(SDS-PAGE): | 55 kDa |
| Allergenicity: | Twenty-three P. acerifolia-sensitized patients with allergic rhinitis in spring were tested. All has positive SPT and sIgE (measured by ImmunoCAP) to plane tree pollen extract. Of those 12 (52%) had serum IgE to recombinant Pla a 5, measured by ELISA. Natural purified Pla a 5 was tested by IgE immunoblot and yielded a positive signal in 4/7 (57%) tested sera. nPla a 5 was also tested by BAT and activated basophils from all three tested Pla a 5-sensitized patients. |
| Route of allergen exposure: | Airway |
| Date Created: | 2022-08-22 |
| Last Updated: | 2022-08-22 18:24:35 |
| Submitter Info: | |
| Name: | Ji-Fu Wei, Jin-Lyu Sun |
| Institution: | Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research & The Affiliated Cancer Hospital of Nanjing Medical University; State Key Laboratory of Complex Severe and Rare Diseases, PUMCH, CAMS |
| City: | Nanjing, China and Beijing, China |
| Email: | weijifu@hotmail.com, sunjinlv@pumch.cn |
| Submission Date: | 2022-08-05 |
Comments
| Isoallergen and variants | GenBank Nucleotide | GenBank Protein | UniProt | PDB |
|---|---|---|---|---|
| Pla a 5.0101 | OK323204 | UYQ90945 |