ALLERGEN NOMENCLATURE
WHO/IUIS Allergen Nomenclature Sub-Committee

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Allergen Details:

Allergen name: Act d 7
Lineage: Source: Plantae Magnoliopsida
Order: Ericales
Species: Actinidia deliciosa (Green Kiwi fruit)
Biochemical name:Pectin methylesterase
MW(SDS-PAGE):50
Allergenicity:IgE prevalence: 32% of 50 kiwi allergic patients in immunoblot
Food allergen:Yes
Date Created:2007-12-18 12:00:00
Last Updated:2010-04-29 16:57:55
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Comments

Posted: 10 Sep 2014

According to the authors Ciardiello et al., 2008, the protein has 4 glycans, some of them are complex N-linked. The deduced MW based on AA sequence is 35 kDa, but tested MW is 50 kDa due to glycosylation. The complex glycan analysis indicates it they are targets of IgE binding for some subjects. Bublin et al., Clin Exp Allergy, 2011 41:129-136 used natural fruit Act d 7 in IgE binding tests that demonstrated IgE binding in 53 of 237 kiwi allergic sera and 53 of 198 kiwi tolerant subjects. REG

Table of IsoAllergens:

Isoallergen and variants GenBank Nucleotide GenBank Protein UniProt PDB
Act d 7.0101 P85076P85076