ALLERGEN NOMENCLATURE
WHO/IUIS Allergen Nomenclature Sub-Committee

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Allergen Details:

Allergen name: Cat r 1
Lineage: Source: Plantae Magnoliopsida
Order: Gentianales
Species: Catharanthus roseus (Rosy periwinkle)
Biochemical name:Cyclophilin
MW(SDS-PAGE):18 kD
Allergenicity:Fifteen subjects from India, all skin prick test positive to extract of Rosy periwinkle (Catharanthus roseus), showed IgE binding to an 18 kDa protein in the extract of pollen. Some showed IgE binding to other proteins. IgE binding using a pool of 5 subjects showed maximum inhibition with recombinant Cat r 1.0101 (cyclophilin), and partial inhibition with recombinant Mala s 6 and Asp f 11. Humanized RBL assay showed activation with sera from five subjects having at least 10% specific release of beta-hexoxaminidase.
Allergenicity reference:24939849
Route of allergen exposure:Unknown
Date Created:Nov 3 2006 8:52PM
Last Updated:2014-07-21 17:37:55
Submitter Info:
Name:Debajyoti Ghosh
Institution:University of Cincinnati College of Medicine
City:Cincinnati, OH, USA
Email:djghosh@yahoo.com
Submission Date:2014-05-08

Comments

Table of IsoAllergens Click +/- for additional information
Isoallergen and variants GenBank Nucleotide GenBank Protein UniProt PDB
Cat r 1.0101X85185CAA59468Q39613 I3QBM4