Allergen Details:
| Allergen name: | Cat r 1 |
|---|---|
| Allergen source: |
Major taxonomic group: Plantae Eudikotyledons Order: Gentianales Species: Catharanthus roseus (Rosy periwinkle) NCBI Taxomony ID: 4058 |
| Biochemical name: | Cyclophilin |
| MW(SDS-PAGE): | 18 kDa |
| Allergenicity: | Fifteen subjects from India, all skin prick test positive to extract of Rosy periwinkle (Catharanthus roseus), showed IgE binding to an 18 kDa protein in the extract of pollen. Some showed IgE binding to other proteins. IgE binding using a pool of 5 subjects showed maximum inhibition with recombinant Cat r 1.0101 (cyclophilin), and partial inhibition with recombinant Mala s 6 and Asp f 11. Humanized RBL assay showed activation with sera from five subjects having at least 10% specific release of beta-hexoxaminidase. |
| Allergenicity reference: | PubMed:24939849 |
| Route of allergen exposure: | Airway |
| Date Created: | 03-11-2006 |
| Last Updated: | 2019-07-30 07:51:40 |
| Submitter Info: | |
| Name: | Debajyoti Ghosh |
| Institution: | University of Cincinnati College of Medicine |
| City: | Cincinnati, OH, USA |
| Email: | djghosh@yahoo.com |
| Submission Date: | 2014-05-08 |
Comments
| Isoallergen and variants | GenBank Nucleotide | GenBank Protein | UniProt | PDB |
|---|---|---|---|---|
| Cat r 1.0101 | X85185 | CAA59468 | Q39613 I3QBM4 |