Allergen Details:
| Allergen name: | Chi t 1 |
|---|---|
| Allergen source: |
Major taxonomic group: Animalia Arthropoda Order: Diptera Species: Chironomus thummi thummi (Midge) NCBI Taxomony ID: 7155 |
| Obsolete name: | Chi t I |
| Biochemical name: | Hemoglobin, component III/IV |
| MW(SDS-PAGE): | 16 kDa |
| Allergenicity: | Of 86 subjects with IgE against C.thummi thummi larvae, 76 had IgE against Chi t I, which comprises 12 homologous hemoglobins (Chi t 1-9). 56 of these 76 people were symptomatic. Chi t I induced histamine release in basophils of all 20 patients tested, and acute rhinitis and/or asthmatic reactions in all 25 patients tested in inhalation challenge test. - Of 15 patients allergic to C.thummi Thummi all had IgE against Chi t 1.01. 13 patients reacted with peptide 80-100 in ELISA: medline 2108351 - Of 15 C.thummi thummi-sensitized patients, all showed IgE binding to Chi t 1.02 in ELISA: medline 21083518. |
| Allergenicity reference: | PubMed:1701849 |
| Route of allergen exposure: | Airway |
| Date Created: | 20-05-2003 |
| Last Updated: | 2019-07-31 07:36:41 |
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Comments
| Isoallergen and variants | GenBank Nucleotide | GenBank Protein | UniProt | PDB |
|---|---|---|---|---|
| Chi t 1.0101 | M17600 | AAA28249 | P02229 | 1ECA |
| Chi t 1.0201 | X00920 | CAA25438 | P02230 |