ALLERGEN NOMENCLATURE
WHO/IUIS Allergen Nomenclature Sub-Committee

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Allergen Details:

Allergen name: Chi t 1
Lineage: Source: Animalia Arthropoda
Order: Diptera
Species: Chironomus thummi thummi (Midge)
Obsolete name:Chi t I
Biochemical name:Hemoglobin, component III/IV
MW(SDS-PAGE):16
Allergenicity:Of 86 subjects with IgE against C.thummi thummi larvae, 76 had IgE against Chi t I, which comprises 12 homologous hemoglobins (Chi t 1-9). 56 of these 76 people were symptomatic. Chi t I induced histamine release in basophils of all 20 patients tested, and acute rhinitis and/or asthmatic reactions in all 25 patients tested in inhalation challenge test. - Of 15 patients allergic to C.thummi Thummi all had IgE against Chi t 1.01. 13 patients reacted with peptide 80-100 in ELISA: medline 2108351 - Of 15 C.thummi thummi-sensitized patients, all showed IgE binding to Chi t 1.02 in ELISA: medline 21083518.
Allergenicity ref.:1701849
Food allergen:No
Date Created:2003-05-20 12:00:00
Last Updated:2012-08-30 09:16:32
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Table of IsoAllergens:

Isoallergen and variants GenBank Nucleotide GenBank Protein UniProt PDB
Chi t 1.0101M17600AAA28249P022291ECA
Chi t 1.0201X00920CAA25438P02230