Allergen Details:
| Allergen name: | Chi t 3 |
|---|---|
| Allergen source: |
Major taxonomic group: Animalia Arthropoda Order: Diptera Species: Chironomus thummi thummi (Midge) NCBI Taxomony ID: 7155 |
| Obsolete name: | Chi t I; Chi t 5, Chi t 6, Chi t 7, Chi t 8 |
| Biochemical name: | Hemoglobin, components II-beta, VI, VII, VIII, IX |
| MW(SDS-PAGE): | 16 kDa |
| Allergenicity: | Of 86 subjects with IgE against C.thummi thummi larvae, 76 had IgE against Chi t I, which comprises 12 homologous hemoglobins (Chi t 1-9). 56 of these 76 people were symptomatic. Chi t I induced histamine release in basophils of all 20 patients tested, and acute rhinitis and/or asthmatic reactions in all 25 patients tested in inhalation challenge test. |
| Allergenicity reference: | PubMed:1701849 |
| Route of allergen exposure: | Airway |
| Date Created: | 22-05-2003 |
| Last Updated: | 2019-07-31 07:39:43 |
| Submitter Info: | |
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Comments
| Isoallergen and variants | GenBank Nucleotide | GenBank Protein | UniProt | PDB |
|---|---|---|---|---|
| Chi t 3.0101 | AF001292 | AAB58932 | P02222 | |
| Chi t 3.0201 | M57411 | AAA69813 | P02224 | |
| Chi t 3.0301 | AF001292 | AAB58930 | P02226 | |
| Chi t 3.0401 | AF001292 | AAB58931 | P02223 | |
| Chi t 3.0501 | M11620 | AAA28260 | P12548 | |
| Chi t 3.0601 | U07703 | AAA85491 | P84296 | |
| Chi t 3.0701 | U07703 U01342 | AAA69815 | P84298 | |
| Chi t 3.0702 | U07703 | AAA85486 | P12549 | |
| Chi t 3.0801 | U07703 | AAA85485 | P12550 | |
| Chi t 3.0901 | P02227 | P02227 |