ALLERGEN NOMENCLATURE
WHO/IUIS Allergen Nomenclature Sub-Committee

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Allergen Details:

Allergen name: Len c 2
Lineage: Source: Plantae Magnoliopsida
Order: Fabales
Species: Lens culinaris (Lentil)
Biochemical name:Seed-specific biotinylated protein
MW(SDS-PAGE):66
Allergenicity:Of 22 lentil-allergic patients tested, 9 (41%) showed IgE binding to purified Len c 2 on immunoblot. IgE binding to Lentil extract was inhibited up to 45% by purified Len c 2 in CAP inhibition assay.
Allergenicity ref.:11080720
Food allergen:Yes
Date Created:2003-06-26 12:00:00
Last Updated:2010-04-29 16:57:55
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Comments

Posted: 21 Jan 2016

No record of the submission, but based on the reference of Sanchez-Monge...Gabriel Salcedo, the peptide list and description, it is from their 2000 paper in JACI, v106:955-961. Note that they have only a few peptides from protease digested and semi-purified fragments that have high identity match to a pea biotinylated seed protein. Only pooled serum immunoblot is shown although claimed that 9 of 22 lentil allergic subjects bound to this protein, without clear description of method or results.

Table of IsoAllergens Click +/- for additional information
Isoallergen and variants GenBank Nucleotide GenBank Protein UniProt PDB
Len c 2.0101