Allergen Details:
| Allergen name: | Per a 1 |
|---|---|
| Allergen source: |
Major taxonomic group: Animalia Arthropoda Order: Blattodea Species: Periplaneta americana (American cockroach) NCBI Taxomony ID: 6978 |
| Obsolete name: | Cr-PII |
| Biochemical name: | Nitrile-specifier, microvilli-like protein with unknown function |
| MW(SDS-PAGE): | 45 kDa |
| Allergenicity: | Of 35 allergic patients, 22 had a positive skin test to CR-extract and Per a 1. Of these 22 patients, 12 (54.4%) showed a positive skin reaction to rPer a 1. IgE Ab binding to rPer a 1 was demonstrated in ELISA. - Amino acid sequences 78LIRALFGL85 and 267IRSWFGLP1274 of the American cockroach Per a 1.0104 allergen were involved in IgE binding, as measured by ELISA. 80%-100% of the sera tested showed IgE binding to these peptides. |
| Allergenicity reference: | PubMed:10221434 PubMed:10329820 |
| Route of allergen exposure: | Airway |
| Date Created: | 16-05-2003 |
| Last Updated: | 2022-06-14 14:56:08 |
| Submitter Info: | |
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Comments
| Isoallergen and variants | GenBank Nucleotide | GenBank Protein | UniProt | PDB |
|---|---|---|---|---|
| Per a 1.0101 | AF072222 | AAD13533 | Q9TZR6 | |
| Per a 1.0102 | U78970 | AAC34312 | O18535 | |
| Per a 1.0103 | U69957 | AAB82404 | O18530 | |
| Per a 1.0104 | U69261 | AAC34737 | O18528 | |
| Per a 1.0201 | U69260 | AAC34736 | O18527 |