Allergen Details:
| Allergen name: | Onc m 1 |
|---|---|
| Allergen source: |
Major taxonomic group: Animalia Chordata Order: Salmoniformes Species: Oncorhynchus mykiss (Rainbow trout) NCBI Taxomony ID: 8022 |
| Biochemical name: | Beta-parvalbumin |
| MW(SDS-PAGE): | 12 kDa |
| Allergenicity: | Fifty fish allergic subjects serum IgE were tested for binding to proteins from Kokane and salmon and mackerel as well as tuna were tested, including Rainbow trout, by ELISA and immunoblots. ELISA values show good correlation between fish, Immunoblot with six subjects allergic to salmon and two sera with high ImmunoCAPs showed strong IgE binding for 4 of eight and weak in two, to 13 kDa band and also a 50 kDa band and 25 kDa. Inhibition with kokanee and red salmon to both showed equal dose/inhibition. From ELISA inhibition of a pool of six sera, rainbow trout and mackerel were able to inhibit binding to kokanee and red salmon within 0.5 log dilution of Red salmon and kokanee, whereas silver salmon was 1 log lower and tuna was < 2 logs lower inhibiting binding. |
| Allergenicity reference: | PubMed:19390241 |
| Route of allergen exposure: | Food |
| Date Created: | 14-04-2011 |
| Last Updated: | 2019-09-05 00:08:03 |
| Submitter Info: | |
| Name: | Heimo Breiteneder |
| Institution: | |
| City: | Vienna |
| Email: | |
| Submission Date: | |
Comments
| Isoallergen and variants | GenBank Nucleotide | GenBank Protein | UniProt | PDB |
|---|---|---|---|---|
| Onc m 1.0101 | P86431 | P86431 | ||
| Onc m 1.0201 | P86432 | P86432 |
There are no full length sequences available for Onc m 1 (yet). The available data suggests that Salmo salar sequences are 95% identical. 13 Dec 2018