ALLERGEN NOMENCLATURE
WHO/IUIS Allergen Nomenclature Sub-Committee

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Allergen Details:

Allergen name: Onc m 1
Lineage: Source: Animalia Chordata
Order: Salmoniformes
Species: Oncorhynchus mykiss (Rainbow trout)
Biochemical name:Beta-parvalbumin
MW(SDS-PAGE):12 kDa
Allergenicity:Fifty fish allergic subjects serum IgE were tested for binding to proteins from Kokane and salmon and mackerel as well as tuna were tested, including Rainbow trout, by ELISA and immunoblots. ELISA values show good correlation between fish, Immunoblot with six subjects allergic to salmon and two sera with high ImmunoCAPs showed strong IgE binding for 4 of eight and weak in two, to 13 kDa band and also a 50 kDa band and 25 kDa. Inhibition with kokanee and red salmon to both showed equal dose/inhibition. From ELISA inhibition of a pool of six sera, rainbow trout and mackerel were able to inhibit binding to kokanee and red salmon within 0.5 log dilution of Red salmon and kokanee, whereas silver salmon was 1 log lower and tuna was < 2 logs lower inhibiting binding.
Allergenicity reference:19390241
Route of allergen exposure:Food
Date Created:
Last Updated:2018-12-14 17:43:14
Submitter Info:
Name:Heimo Breiteneder
Institution:
City:Vienna
Email:
Submission Date:

Comments

Posted: 14 Dec 2018

There are no full length sequences available for Onc m 1 (yet). The available data suggests that Salmo salar sequences are 95% identical. 13 Dec 2018

Table of IsoAllergens Click +/- for additional information
Isoallergen and variants GenBank Nucleotide GenBank Protein UniProt PDB
Onc m 1.0101 P86431P86431 
Onc m 1.0201 P86432P86432