Allergen Details:
| Allergen name: | Ara h 12 |
|---|---|
| Allergen source: |
Major taxonomic group: Plantae Eudikotyledons Order: Fabales Species: Arachis hypogaea (Peanut, groundnut) NCBI Taxomony ID: 3818 |
| Biochemical name: | Defensin |
| MW(SDS-PAGE): | 8 kDa (reducing), 12 kDa (non-reducing), 5.184 kDa (mass) |
| Allergenicity: | Four peanut allergic subjects with clear clinical histories and high IgE by ImmunoCAP to peanut had demonstrable IgE binding to non-reduced defensins. BAT was positive for a few subjects to a mixture of Ara h 12 and Ara h 13. |
| Allergenicity reference: | PubMed:26037551 |
| Route of allergen exposure: | Food |
| Date Created: | 03-07-2012 |
| Last Updated: | 2020-05-14 17:12:24 |
| Submitter Info: | |
| Name: | Arnd Petersen; Sandra Rennert; Wolf-Meinhard Becker; Susanne Krause; Thomas Gutsmann; Buko Lindner; Uta Jappe |
| Institution: | Research Center Borstel, Division of Clinical and Molecular Allergology, Research Center Borstel, Airway Research Center North (ARCN), Member of the German Center for Lung Research (DZL) |
| City: | Borstel, Germany |
| Email: | ujappe@fz-borstel.de |
| Submission Date: | 2012-07-03 |
Comments
| Isoallergen and variants | GenBank Nucleotide | GenBank Protein | UniProt | PDB |
|---|---|---|---|---|
| Ara h 12.0101 | EY396089 | B3EWP3 |
Communicated with Uta Jappe a number of times. The publication in JACI 2015 is quite good (Petersen). However, the EST predicts a longer protein and the MW in the publication suggests that a longer sequence of ~ 8kDa is present in the extract. The proteins are NOT very soluble in PBS and most extracts miss them.