ALLERGEN NOMENCLATURE
WHO/IUIS Allergen Nomenclature Sub-Committee

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Allergen Details:

Allergen name: Ara h 13
Lineage: Source: Plantae Magnoliopsida
Order: Fabales
Species: Arachis hypogaea (Peanut, groundnut)
Biochemical name:Defensin
MW(SDS-PAGE):8 kDa (reducing), 11 kDa (non-reducing), 5.472 kDa (mass)
Allergenicity:Five peanut allergic subjects with high peanut extract ImmunoCAP showed IgE binding to Ara h 13 in non-reducing immunoblot. Also at least two subjects had positive BAT to a mixture of Ara h 12 and Ara h 13.
Allergenicity ref.:26037551
Food allergen:Yes
Date Created:2015-12-23 12:00:00
Last Updated:2016-10-11 13:06:38
Submitter Info:
Name:Arnd Petersen; Sandra Rennert; Wolf-Meinhard Becker; Susanne Krause; Thomas Gutsmann; Buko Lindner; Uta Jappe
Institution:Research Center Borstel, Division of Clinical and Molecular Allergology, Research Center Borstel, Airway Research Center North (ARCN), Member of the German Center for Lung Research (DZL)
City:Borstel, Germany
Email:apetersen@fz-borstel.de
Date:2012-07-03

Comments

Posted: 23 Dec 2015

Communicated with Uta Jappe a number of times. The publication in JACI 2015 is quite good (Petersen). However, the EST predicts a longer protein and the MW in the publication suggests that a longer sequence of ~ 8kDa is present in the extract. The proteins are NOT very soluble in PBS and most extracts miss them.

Table of IsoAllergens:

Isoallergen and variants GenBank Nucleotide GenBank Protein UniProt PDB
Ara h 13.0101EY396019   
Ara h 13.0102EE124955