ALLERGEN NOMENCLATURE
WHO/IUIS Allergen Nomenclature Sub-Committee

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Allergen Details:

Allergen name: Asc l 13
Lineage: Source: Animalia Nematoda
Order: Ascaridida
Species: Ascaris lumbricoides (Common roundworm)
Biochemical name:Glutathione S-transferase (GST)
MW(SDS-PAGE):23 kDa
Allergenicity:26 (90%) of 29 patients exposed to A. lumbricoides with positive CAP to A. lumbricoides showed IgE binding to purified natural Asc l 13 in ELISA. Of 12 patients tested by SPT with nAsc l 13, 5 (42%) reacted. The identity of the natural purified Asc l 13 was established by sequencing 73% of the protein by MS/MS.
Allergenicity ref.:24223794
Food allergen:No
Date Created:2014-09-08 12:00:00
Last Updated:2016-10-11 12:50:31
Submitter Info:
Name:Luis Caraballo
Institution:University of Cartagena, Institute for Immunological Research
City:Cartagena, Colombia
Email:lcaraballog@unicartagena.edu.co
Date:2013-05-18

Comments

Posted: 09 Jan 2014

The 'w' at the end of the allergen isoform designation signifies that an authentic and complete cDNA sequence encoding this allergen is not available (see 'Sequence features" of Asc l 13.0101w below.

Posted: 08 Sep 2014

The glutathione transferase of Ascaris lumbricoides and Ascaris suum are nearly identical. Serum IgE from a number of subjects in Cartagena showed IgE binding to both in the published article in PLOS ONE.

Table of IsoAllergens Click +/- for additional information
Isoallergen and variants GenBank Nucleotide GenBank Protein UniProt PDB
Asc l 13.0101wBU585392P46436P46436 (Ascaris suum GST)