ALLERGEN NOMENCLATURE
WHO/IUIS Allergen Nomenclature Sub-Committee

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Allergen Details:

Allergen name: Act d 12
Lineage: Source: Plantae Magnoliopsida
Order: Ericales
Species: Actinidia deliciosa (Green Kiwi fruit)
Biochemical name:Cupin, 11S globulin
MW(SDS-PAGE):50,207.304 Da (mass spectrometry), 6 peptide sequences (C0HJF9, to be released upon publication))
Allergenicity:Sera from 39 of 55 kiwifruit allergic individuals had IgE that reacted with the purified natural Act d 12 in immunobolots and ELISA. Basophil activation tests of 3 of 4 patients with the purified nAct d 12 were positive. SPTs of 4 of 4 patients with the purified nAct d 12 were positive.
Food allergen:Yes
Date Created:2014-02-14 12:00:00
Last Updated:2016-10-11 13:08:41
Submitter Info:
Name:Oscar Palomares
Institution:School of Chemistry, Complutense University of Madrid, Department of Biochemistry and Molecular Biology
City:Madrid, Spain
Email:oscar.palomares@quim.ucm.es
Date:2013-11-28

Comments

Posted: 29 Feb 2016

The full sequence of kiwi Act d 12 was not determined in the Palomares submission. The six pepetide sequences provided are obtained from the allergenic protein purified from Actinidia deliciosa. These peptides match with the available cDNA sequence for an 11S globulin-like protein from Actinidia chinensis. The new allergen (Act d 12) has been identified, purified and characterized from Actinidia deliciosa. The order of peptides (partial sequence) are based on the known sequence of Actinidia chinensis 11S. 24 Feb 2016

Table of IsoAllergens Click +/- for additional information
Isoallergen and variants GenBank Nucleotide GenBank Protein UniProt PDB
Act d 12.0101