ALLERGEN NOMENCLATURE
WHO/IUIS Allergen Nomenclature Sub-Committee

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Allergen Details:

Allergen name: Act d 13
Lineage: Source: Plantae Magnoliopsida
Order: Ericales
Species: Actinidia deliciosa (Green Kiwi fruit)
Biochemical name:2S albumin
MW(SDS-PAGE):11,359,6 Da (mass spectrometry), 4 peptide seqeunces (C0HJG, to be released upon publication)
Allergenicity:Sera from 10 of 55 kiwifruit allergic individuals had IgE that reacted with the purified natural Act d 13 in immunobolots and ELISA. A basophil activation test of 1 patient with the purified nAct d 13 was positive. A SPT of 1 patient with the purified nAct d 13 was positive.
Allergenicity ref.:25041438 , 24990823
Food allergen:Yes
Date Created:2016-02-24 12:00:00
Last Updated:2016-10-11 13:08:54
Submitter Info:
Name:Oscar Palomares
Institution:School of Chemistry, Complutense University of Madrid, Department of Biochemistry and Molecular Biology
City:Madrid, Spain
Email:oscar.palomares@quim.ucm.es
Date:2013-11-28

Comments

Posted: 29 Feb 2016

There is no clear complete sequence for Act d 13. Sirvent S, et al., 2014 in a note in JACI show purification and biochemical characterization, but only four peptide sequences (by MS) that show partial sequence identities to a mustard 2S (Sin a 1, uniprot P15322) and to Brassica rapa or napus. The paper by Sirvent, Canto et al., 2014 Allergy) does not show sequence identity or refer to sequence. Neither does the paper by Nilsson et al., Ped Allergy and Immunology 2015. Unless a sequence can be determined and published that clearly represents this 2S albumin from kiwi, the identity of the allergen is not certain.

Table of IsoAllergens:

Isoallergen and variants GenBank Nucleotide GenBank Protein UniProt PDB