ALLERGEN NOMENCLATURE
WHO/IUIS Allergen Nomenclature Sub-Committee

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Allergen Details:

Allergen name: Der f 29
Lineage: Source: Animalia Arthropoda
Order: Astigmata
Species: Dermatophagoides farinae (American house dust mite)
Biochemical name:Peptidyl-prolyl cis-trans isomerase (cyclophilin)
MW(SDS-PAGE):16 kD
Allergenicity:35 of 41 HDM sensitized subjects had IgE binding to Der f 29, cyclophilin, by immunoblot, 9 shown in publication. The nine were positive by ELISA and activated CCR3 >20% in BAT. In addition, 7 or 10 HDM allergic subjects were SPT + to rDer f 29.
Allergenicity ref.:23481662
Food allergen:No
Date Created:2014-11-07 12:00:00
Last Updated:2016-10-11 12:54:43
Submitter Info:
Name:Su An
Institution:Kunming Institute of Zoology, Chinese Academy of Sciences
City:Kunming, China
Email:aslxj@mail.ustc.edu.cn
Date:2013-10-17

Comments

Posted: 04 Nov 2014

NOTE: Zhiling Liang; Jianli Lin; Zhigang Liu; Pingchang Yang; Yulan Wu; Xiaoyu Liu submitted an identical protein sequence to IUIS on 2014-10-17 before we posted the An Su sequence. Liang et al., state that their protein was 19 kDa, nucleotide accession KM010000, but called it Der f 26. However due to prior submission Su An submission takes precedent. For allergenicity Liang et al., stated 9 of 52 subjects were SPT positive with recombinant, and 5 of 5 were positive by immunoblot and ELISA testing IgE.

Posted: 01 Jun 2016

NOTE: NCBI and UniProt show "Der f 29" as profilin, but that entry (Accession AIO08866.1) was not submitted to IUIS and is illegitimate.

Table of IsoAllergens:

Isoallergen and variants GenBank Nucleotide GenBank Protein UniProt PDB
Der f 29.0101AY283280.1AAP35065A1KXG2