Allergen Details:
| Allergen name: | Sola l 6 |
|---|---|
| Allergen source: |
Major taxonomic group: Plantae Eudikotyledons Order: Solanales Species: Solanum lycopersicum (Lycopersicon esculentum) (Tomato) NCBI Taxomony ID: 4081 |
| Biochemical name: | Non-specific lipid transfer protein type 2 (nsLTP2) |
| MW(SDS-PAGE): | 7 kDa |
| Allergenicity: | The majority of 20 tomato allergic Italian subjects showed IgE binding to Sola l 6 by ISAC |
| Allergenicity reference: | PubMed:25791776 PubMed:26840232 |
| Route of allergen exposure: | Food |
| Date Created: | 23-05-2015 |
| Last Updated: | 2019-09-26 07:08:39 |
| Submitter Info: | |
| Name: | Maria Antonietta Ciardiello |
| Institution: | National Research Council, Institute of Biosciences and Bioresources |
| City: | Naples, Italy |
| Email: | mariaantonietta.ciardiello@ibbr.cnr.it |
| Submission Date: | 2014-12-29 |
Comments
A second group, Mayte Villalba et al., from Madrid has submitted the same sequence, but a full-length sequence for a name for this LTP to IUIS prior to the Giangrieco entry, but with incomplete information. They presented at a Spanish Congress XXXVII SEBBM at Granada, Spain abstr P06r-2, in 2014. They claim 16 of 28 tomato allergic subjects had IgE binding by Western and ELISA, 5 of 7 were SPT+ and 5 of 7 were positive by BAT. They claim to have had 69% coverage of the cited full-length sequence of EST referenced by Giangrieco, XP_004232333. Both groups (L. Martin-Pedraza et al., and Giangrieco et al., deserve to be recognized for their contributions.
| Isoallergen and variants | GenBank Nucleotide | GenBank Protein | UniProt | PDB |
|---|---|---|---|---|
| Sola l 6.0101 | XP_004232333 | A0A3Q7F7X3 |
Although the abstract by Giangrieco et al. (Maria Antonietta Ciardello) indicates that a few of the tomato allergic subjects were monosensitized to Sola l 6, they must have meant monosensitized to LTP as a number had as much or higher IgE to other LTPs and even those with high IgE to the 7kD tomato LTP had high IgE to at least one other species LTP based on table 2 of the Mol. Immunology paper.