ALLERGEN NOMENCLATURE
WHO/IUIS Allergen Nomenclature Sub-Committee

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Allergen Details:

Allergen name: Ara h 15
Lineage: Source: Plantae Magnoliopsida
Order: Fabales
Species: Arachis hypogaea (Peanut, groundnut)
Obsolete name:Oleosin 3
Biochemical name:Oleosin
MW(SDS-PAGE):17 kDa
Allergenicity:15 of 33 subjects with peanut allergy had demonstrable IgE binding to this protein (based on communication with submission)
Allergenicity reference:25860789
Route of allergen exposure:Food
Date Created:
Last Updated:2016-10-11 20:10:03
Submitter Info:
Name:Uta Jappe, Christian Schwager, Skadi Kull, Susanna Krause, Frauke Schocker, Arnd Petersen, Wolf-Meinhard Becker
Institution:Research Center Borstel, Division of Clinical and Molecular Allergology, Research Center Borstel, Airway Research Center North (ARCN), Member of the German Center for Lung Research (DZL)
City:Borstel, Germany
Email:ujappe@fz-borstel.de
Submission Date:2015-03-27

Comments

Posted: 02 May 2015

From submission: Results obtained from N-terminal sequencing and peptide mass fingerprinting of the protein gave reliable evidence that this proteins refers to the amino acid sequence from Uniprot Q647G3, a peanut oleosin. Therefore, a new allergen name is suggested. Sequence identity to the registered peanut oleosins Ara h 10 and Ara h 11 is below 48%. In addition, the sequence identity to the submitted allergen Ara h 14 is below 30 % (Alignments were performed using ClustalW2, https://www.ebi.ac.uk/Tools/msa/clustalw2).

Table of IsoAllergens Click +/- for additional information
Isoallergen and variants GenBank Nucleotide GenBank Protein UniProt PDB
Ara h 15.0101AY722696AAU21501Q647G3