Allergen Details:
| Allergen name: | Per a 12 |
|---|---|
| Allergen source: |
Major taxonomic group: Animalia Arthropoda Order: Blattodea Species: Periplaneta americana (American cockroach) NCBI Taxomony ID: 6978 |
| Biochemical name: | Chitinase |
| MW(SDS-PAGE): | 45 kDa |
| Allergenicity: | Sera from 30 of 40 (63.8%) patients reacted to Per a 12 on immunoblots. ELISA inhibition of serum IgE reactivity to the cockroach midgut extract (CME) using purified Per a 12 was significant (40%). Nine of 15 (60%) cockroach-allergic patients had positive SPT reactions to Per a 12. In comparison with healthy control, Per a 12 at 1.0 g/ml induced approximately up to 5-fold increase in the number of CD63 and CCR3 double-positive cells following incubating it with PBMC from patients with cockroach allergy |
| Allergenicity reference: | PubMed:26361742 |
| Route of allergen exposure: | Airway |
| Date Created: | 02-06-2015 |
| Last Updated: | 2020-03-24 19:42:52 |
| Submitter Info: | |
| Name: | Su An |
| Institution: | Kunming Institute of Zoology, Chinese Academy of Sciences |
| City: | Kunming, China |
| Email: | aslxj@mail.ustc.edu.cn |
| Submission Date: | 2015-05-05 |
Comments
| Isoallergen and variants | GenBank Nucleotide | GenBank Protein | UniProt | PDB |
|---|---|---|---|---|
| Per a 12.0101 | KR019686 | AKH04311 |