ALLERGEN NOMENCLATURE
WHO/IUIS Allergen Nomenclature Sub-Committee

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Allergen Details:

Allergen name: Aed a 4
Lineage: Source: Animalia Arthropoda
Order: Diptera
Species: Aedes aegypti (Yellow fever mosquito)
Biochemical name:α-glucosidase
MW(SDS-PAGE):67 kDa
Allergenicity:Subjects were allergic to mosquito bites. 13 of 13 were positive to challenge bites of mosquito, Aedes aegypti, 18 controls were negative. 6 of 13 subjects were IgE binding positive to recombinant Aed a 4 by ELISA, 18 controls were negative. ELISA and ELISA inhibition were performed with native (extract of head and thorax) and recombinant Aed a 4 produced in baculovirus insect cell line.
Allergenicity ref.:17620829 18220995 25661054
Food allergen:No
Date Created:2016-03-13 12:00:00
Last Updated:2016-10-11 12:59:32
Submitter Info:
Name:Zhikang Peng
Institution:University of Manitoba, Dept. of Pediatrics and Child Health
City:Winnipeg, Canada
Email:zpeng@umanitoba.ca
Date:2016-02-22

Comments

Posted: 12 Mar 2016

On 30 December, 2015 a different protease from mosquito was entered as Aed a 4, from Jose Cantillo. In a review of information in March, 2016 a decision was made that the designation Aed a 4 should below to a protease identified in 2001 by Z Peng. The Cantillo entry became Aed a 11. The Peng protein and information was input on 12 March, 2016 as Aed a 4.0101 by REG

Table of IsoAllergens:

Isoallergen and variants GenBank Nucleotide GenBank Protein UniProt PDB
Aed a 4.0101M30442.1P13080