ALLERGEN NOMENCLATURE
WHO/IUIS Allergen Nomenclature Sub-Committee

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Allergen Details:

Allergen name: Cup s 2
Lineage: Source: Plantae Pinopsida
Order: Cupressales
Species: Cupressus sempervirens (Common cypress)
Biochemical name:Polygalacturonase
MW(SDS-PAGE):43 kDa
Allergenicity:sera from 19 of 31 subjects with airway allergy in areas exposed to Common cypress (Curessus sempervirens) were positive to a 43 kDa protein based on immunoblots. The protein was characterized and demonstrated to be highly identical to Jun a 2 (~95% identity) and to Cha o 2 (80%).
Food allergen:No
Date Created:2017-01-11 16:03:09
Last Updated:2017-01-11 16:03:09
Submitter Info:
Name:Pascal Ponset
Institution:Institut Pasteur
City:Paris, France
Email:pascal.poncet@pasteur.fr
Date:2016-12-09

Comments

Posted: 11 Jan 2017

Ten reads of LC-MSMS produced 33 overlapping peptides with high identity match to a homologous protein from Cupressus arizonica and to Juniperus ashei, with >74% coverage. Edmand degradation was used to identify the N-terminus. That sequence was submitted to UniProt as C0HKB1, which is not yet posted.

Table of IsoAllergens:

Isoallergen and variants GenBank Nucleotide GenBank Protein UniProt PDB