ALLERGEN NOMENCLATURE
WHO/IUIS Allergen Nomenclature Sub-Committee

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Allergen Details:

Allergen name: Art an 7
Lineage: Source: Plantae Magnoliopsida
Order: Asterales
Species: Artemisia annua (Sweet Wormwood)
Biochemical name:Putative Galactose Oxidase
MW(SDS-PAGE):62 kDa
Allergenicity:Case history of weed pollen inhalation allergy, in vitro IgE to mugwort extract, to natural purified protein (15 Chinese subjects by reducing immunoblot) and 125 of 130 Chinese subjects by ImmunoCAP, 15 of 15 by IgE reducing immunoblot, but fewer with recombinant protein as seen in draft manuscript. With only one clearly positive in ImmunoCAP with recombinant protein. Dutch pollen allergic subjects, 19 of 20 were positive by natural purified protein ImmunoCAP, but only 10 to recombinant protein, and those values were only modest (>0.35 kUA to 1.8 kUA). Four of 8 Chinese subjects were positive to natural pure protein by SPT. There is some possible involvement of carbohydrate (CCD+ and also possibly to arabinofuranosides based on paper by Xie Ning and CM Taylor, 2014).
Allergenicity reference:29220102
Route of allergen exposure:Airway
Date Created:2017-12-02
Last Updated:2018-12-02 21:12:30
Submitter Info:
Name:Zhong-shan Gao
Institution:Zhejiang University, Allergy Research Center and Horticulture Dept.
City:Hangzhou, China
Email:gaozhongshan@zju.edu.cn
Submission Date:2017-01-15

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Table of IsoAllergens Click +/- for additional information
Isoallergen and variants GenBank Nucleotide GenBank Protein UniProt PDB
Art an 7.0101KY428925ARQ16437