ALLERGEN NOMENCLATURE
WHO/IUIS Allergen Nomenclature Sub-Committee

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Allergen Details:

Allergen name: Fag e 4
Lineage: Source: Plantae Magnoliopsida
Order: Caryophyllales
Species: Fagopyrum esculentum (Common buckwheat)
Obsolete name:Fa-AMP
Biochemical name:Antimicrobial Peptide
Allergenicity:Seven serum donors with convincing case histories of buckwheat allergy were tested. Food challenges were performed with positive outcome in 3/7 patients whereas not done in 4/7. SPTs were performed using total extract of the source as well as for oral food challenges. Serum derived IgE to native proteins from the extract was tested by western blot (6/7 positive). 5/7 samples were positive to purified Fag e 4 in ELISA. Natural exposure is by ingestion. Controls were performed with sera from 5 healthy donors, and 28 sera from atopic controls.
Allergenicity reference:29171912
Route of allergen exposure:Food
Date Created:
Last Updated:2018-10-31 17:32:58
Submitter Info:
Name:Karin Hoffmann-Sommergruber
Institution:Medical University of Vienna
City:Vienna, Austria
Email:karin.hoffmann@muv.ac.at
Submission Date:2017-02-13

Comments

Posted: 21 Apr 2017

Fag e 4 used as parent number since other members of Caryophyllales have Oleosin-like protein as #1, and #2 and #3 are already used.

Table of IsoAllergens Click +/- for additional information
Isoallergen and variants GenBank Nucleotide GenBank Protein UniProt PDB
Fag e 4.0101  P0DKH7 
Fag e 4.0102  P0DKH8