Allergen Details:
| Allergen name: | Der f 23 |
|---|---|
| Allergen source: |
Major taxonomic group: Animalia Arthropoda Order: Sarcoptiformes Species: Dermatophagoides farinae (American house dust mite) NCBI Taxomony ID: 6954 |
| Biochemical name: | Peritrophin-A-like protein |
| MW(SDS-PAGE): | 19 kDa (Der f 23.01), 8 kDa (Der f 23.02) |
| Allergenicity: | Subjects clinical history was recorded with symptoms of rhinitis or bronchial asthma. Serum IgE reactions to Der f 23.0101 were measured including western blots, dot blots and ELISA, with 72 positive reactors out of 129 patients, and 31 negative controls for IgE binding. SPT was positive for 3 subjects out of 10 patients and 10 controls. E. coli produced recombinant protein was used in IgE binding and SPT tests. |
| Allergenicity reference: | PubMed:31173194 |
| Route of allergen exposure: | Airway |
| Date Created: | 04-05-2018 |
| Last Updated: | 2023-11-09 14:37:53 |
| Submitter Info: | |
| Name: | Kunmei Ji, Jiajie Chen |
| Institution: | Shenzhen University Health Center |
| City: | Shenzhen, China |
| Email: | jkm@szu.edu.cn, chenjj@szu.edu.cn |
| Submission Date: | 2018-04-19 |
Comments
| Isoallergen and variants | GenBank Nucleotide | GenBank Protein | UniProt | PDB |
|---|---|---|---|---|
| Der f 23.0101 | KU166910 | ALU66112 | A0A0U3JM87 | 5ZJL |
| Der f 23.0201 | KM009999 | AIO08855 | A0A088SAW7 |
Der f 23.01 (19 kDa) differs from Der f 23.02 (8 kDa) by two large insertions in the sequence, while the overlapping parts of the protein sequences are identical. The shorter isoallergen (i.e. Der f 23.02) corresponds in its length to Der p 23.01 with 76% amino acid sequence identity.