ALLERGEN NOMENCLATURE
WHO/IUIS Allergen Nomenclature Sub-Committee

Financial contribution from IUIS, EAACI, and AAAAI organizations

Member Login

Allergen Details:

Allergen name: Lat c 6
Lineage: Source: Animalia Chordata
Order: Perciformes
Species: Lates calcarifer (Barramundi)
Biochemical name:Collagen alpha
MW(SDS-PAGE):130 kDa to 140 kDa
Allergenicity:Lat c 6 Allergenicity: Sera of 87 fish-allergic patients were tested for IgE binding to a pool of barramundi, Atlantic salmon and Yellowfin tuna collagens by ELISA. 19 patients were positive. Of those, 13 sera were tested in immunoblots to check IgE binding to collagen from specific fish species and to specific collagen alpha chains. Of 13 sera tested in immunoblot, IgE from all 13 bound to collagen alpha 1 chain from muscle tissue of barramundi. 11 of 13 bound to alpha 2 chain from muscle and to alpha 1 and alpha 2 chains from skin. Basophil activation test was performed with whole blood of one of the collagen-sensitized patients, using barramundi muscle collagen as stimulant of basophils. The result was positive.
Allergenicity reference:27082250
Route of allergen exposure:Food
Date Created:18/04/2019
Last Updated:2019-05-01 03:55:58
Submitter Info:
Name:Tanja Kalic; Andreas L Lopata
Institution:Medical University of Vienna; James Cook University
City:Vienna, Austria; Townsville, Australia
Email:tanja.kalic@meduniwien.ac.at; andreas.lopata@jcu.edu.au
Submission Date:2019-03-23

Comments

Table of IsoAllergens Click +/- for additional information
Isoallergen and variants GenBank Nucleotide GenBank Protein UniProt PDB
Lat c 6.0101XM_018666207.1XP_018521723.1  
Lat c 6.0201XM_018698476.1XP_018553992.1  
Lat c 6.0301XM_018666614.1XP_018522130.1