ALLERGEN NOMENCLATURE
WHO/IUIS Allergen Nomenclature Sub-Committee

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Allergen Details:

Allergen name: Sal s 6
Lineage: Source: Animalia Chordata
Order: Salmoniformes
Species: Salmo salar (Atlantic salmon)
Biochemical name:Collagen alpha
MW(SDS-PAGE):130-140 kDa
Allergenicity:Sal s 6 Allergenicity: Sera of 87 fish-allergic patients were tested for IgE binding to a pool of barramundi, Atlantic salmon and Yellowfin tuna collagens by ELISA. 19 patients were positive. Of those, 13 sera were tested in immunoblots to check IgE binding to collagen from specific fish species and to specific collagen alpha chains. Of 13 sera tested in immunoblot, IgE from 11 bound to collagen alpha 1 and alpha 2 chains from muscle and skin tissue of Atlantic salmon. Basophil activation test was performed with whole blood of one of the collagen-sensitized patients, using salmon muscle collagen as stimulant of basophils. The result was positive.
Allergenicity reference:unpublishedsofar
Route of allergen exposure:Food
Date Created:19/04/2019
Last Updated:2019-05-01 03:54:27
Submitter Info:
Name:Tanja Kalic; Andreas L Lopata
Institution:Medical University of Vienna; James Cook University
City:Vienna, Austria; Townsville, Australia
Email:tanja.kalic@meduniwien.ac.at; andreas.lopata@jcu.edu.au
Submission Date:2019-03-23

Comments

Table of IsoAllergens Click +/- for additional information
Isoallergen and variants GenBank Nucleotide GenBank Protein UniProt PDB
Sal s 6.0101XM_014204457.1XP_014059932.1  
Sal s 6.0102XM_014192569.1XP_014048044.1  
Sal s 6.0201XM_014142822.1XP_013998297.1  
Sal s 6.0202XM_014178510.1XP_014033985.1