ALLERGEN NOMENCLATURE
WHO/IUIS Allergen Nomenclature Sub-Committee

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Allergen Details

Allergen name: Can s 4
Allergen source: Major taxonomic group: Plantae Eudikotyledons
Order: Rosales
Species: Cannabis sativa (Indian hemp)
NCBI Taxomony ID: 3483
Biochemical name:Oxygen evolving Enhancer Protein 2
MW(SDS-PAGE):27.3 kDa
Allergenicity:A total of 118 subjects, 113 with immediate symptoms upon exposure by inhalation (113 and two upon ingestion to cannabis, 30 healthy controls adn 45 with individual pollen or nsLTP sensitization were tested for IgE binding. 8 bound to the recombinant protein by CBA test. Three were positive by basophil activation. Not published yet
Allergenicity reference:PubMed:32298851
Route of allergen exposure:Airway
Created:2020-02-28 17:09:02
Last Updated:2024-10-04 16:15:57
Submitter Info:
Name:Hans-Peter Rihs
Institution:Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA), Institute of the Ruhr-University Bochum
City:Bochum, Germany
Email:rihs@ipa-dguv.de
Submission Date:2019-09-30

Comments

Posted: 28 Feb 2020

113 subjects reacted immediately after inhalation. Two subjects reacted following ingestion based on submitter comments. This is a green tissue protein

Table of Isoallergens

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Isoallergen and variants GenBank Nucleotide GenBank Protein UniProt PDB
Can s 4.0101XM_030626708.1XP_030482568.1