WHO/IUIS Allergen Nomenclature Sub-Committee

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Allergen Details:

Allergen name: Can s 4
Allergen source: Major taxonomic group: Plantae Eudikotyledons
Order: Rosales
Species: Cannabis sativa (Indian hemp)
NCBI Taxomony ID: 3483
Biochemical name:Oxygen evolving Enhancer Protein 2
MW(SDS-PAGE):27.3 kDa
Allergenicity:A total of 118 subjects, 113 with immediate symptoms upon exposure by inhalation (113 and two upon ingestion to cannabis, 30 healthy controls adn 45 with individual pollen or nsLTP sensitization were tested for IgE binding. 8 bound to the recombinant protein by CBA test. Three were positive by basophil activation. Not published yet
Route of allergen exposure:Airway
Date Created:2020/2/27
Last Updated:2020-03-02 17:14:35
Submitter Info:
Name:Hans-Peter Rihs
Institution:IPA, Molecular Genetics
City:Bochum, Germany
Submission Date:2019-09-30


Posted: 28 Feb 2020

113 subjects reacted immediately after inhalation. Two subjects reacted following ingestion based on submitter comments. This is a green tissue protein

Table of IsoAllergens Click +/- for additional information
Isoallergen and variants GenBank Nucleotide GenBank Protein UniProt PDB
Can s 4.0101XM_030626708.1XP_030482568.1