Allergen Details
| Allergen name: | Mac i 1 |
|---|---|
| Allergen source: |
Major taxonomic group: Plantae basal Mesangiosperms Order: Proteales Species: Macadamia integrifolia (Macadamia) NCBI Taxomony ID: 60698 |
| Biochemical name: | Vicilin |
| MW(SDS-PAGE): | 50 kDa |
| Allergenicity: | Sera of 8 Macadamia nut allergic subjects were tested for IgE binding to purified natural protein by ELISA and four were positive. The protein was confirmed by LC-MSMS. There is a Pro-peptide of ~ 179 AA, and the mature peptide from 180-625 AA. The submitters indicate the protein is glycosylated, but the glycan does not bind IgE, the protein does. |
| Allergenicity reference: | PubMed:34525424 |
| Route of allergen exposure: | Food |
| Created: | 2020-08-26 01:11:52 |
| Last Updated: | 2023-03-28 17:52:25 |
| Submitter Info: | |
| Name: | Stefan Kabasser; Merima Bublin |
| Institution: | Medical University of Vienna, Institute of Pathophysiology and Allergy Research |
| City: | Vienna, Austria |
| Email: | stefan.kabasser@meduniwien.ac.at, merima.bublin@meduniwien.ac.at |
| Submission Date: | 2020-08-06 |
Comments
Table of Isoallergens
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| Isoallergen and variants | GenBank Nucleotide | GenBank Protein | UniProt | PDB |
|---|---|---|---|---|
| Mac i 1.0101 | AAD54246.1 | Q9SPL3 | ||
| Mac i 1.0101 (28-76) | AAD54245.1 | Q9SPL4 |