WHO/IUIS Allergen Nomenclature Sub-Committee

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Allergen Details:

Allergen name: Man i 4
Allergen source: Major taxonomic group: Plantae Eudikotyledons
Order: Sapindales
Species: Mangifera indica (Mango)
NCBI Taxomony ID: 29780
Biochemical name:Profilin
Allergenicity:Sixty-one sera from mango-allergic patients (as defined by history) were tested by IgE-ELISA. Of those, 24 (39%) had IgE to rMal i 4.0101. In the subgroup of 26 patients with mango ImmunoCAP > 0.35 kU/L, 16 (62%) were sensitized to Man i 4.0101. IgE-levels to Man I 4.0101 correlated with IgE to Art an 4.0101 (profilin from sweet wormwood pollen). 12 sera from mango allegric patients who were sensitized to Man i 4.0101 were also tested with rMan i 4.0102 by IgE ELISA. All sera also reacted to Man i 4.0102, albeit with significantly lower signals.
Allergenicity reference:PubMed:36724175
Route of allergen exposure:Food
Date Created:2022/02/23
Last Updated:2023-04-03 18:37:02
Submitter Info:
Name:Zhong-Shan Gao; Lan Zhao
Institution:Zhejiang University, College of Agriculture and Biotechnology
City:Hangzhou, China;
Submission Date:2022-01-29


Table of IsoAllergens Click +/- for additional information
Isoallergen and variants GenBank Nucleotide GenBank Protein UniProt PDB
Man i 4.0101OK136959UYO79700  
Man i 4.0102OK136960UYO79701