WHO/IUIS Allergen Nomenclature Sub-Committee

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Allergen Details:

Allergen name: Hum j 6
Allergen source: Major taxonomic group: Plantae Eudikotyledons
Order: Rosales
Species: Humulus japonicus (Japanese hop)
NCBI Taxomony ID: 3485
Biochemical name:Pectin methylesterase inhibitor (PMEI; pectinesterase inhibitor)
MW(SDS-PAGE):10-15 kDa
Allergenicity:Twenty-two patients with respiratory allergy who were sensitized to Japanese hop (specific IgE measured by ImmunoCAP) were tested. Of those, 19 (86%) had IgE to natural Hum j 6 purified from Humulus japonicus pollen as determined by ELISA. In contrast, recombinant allergens produced in E. coli Origami and Pichia pastoris bound only low amounts of IgE from 10 and 11 sera, respectively. The natural allergen is highly phosphorylated, but dephosphorylation did not affect IgE binding, as determined by immunoblot.
Route of allergen exposure:Airway
Date Created:
Last Updated:2022-06-14 18:01:14
Submitter Info:
Name:Kyoung Yong Jeong, Jung-Won Park
Institution:Yonsei University College of Medicine
City:Seoul, Korea,
Submission Date:2022-05-04


Table of IsoAllergens Click +/- for additional information
Isoallergen and variants GenBank Nucleotide GenBank Protein UniProt PDB
Hum j 6.0101ON399181