WHO/IUIS Allergen Nomenclature Sub-Committee

Financial contributions from IUIS, EAACI, and AAAAI

Member Login

Allergen Details:

Allergen name: Pla a 4
Allergen source: Major taxonomic group: Plantae basal Mesangiosperms
Order: Proteales
Species: Platanus acerifolia (London plane tree)
NCBI Taxomony ID: 140101
Biochemical name:Profilin
MW(SDS-PAGE):13.5 kDa
Allergenicity:Thirty-nine P. acerifolia-sensitized patients with allergic rhinitis in spring were tested. All has positive SPT and sIgE (measured by ImmunoCAP) to plane tree pollen extract. Of those 30 (77%) had serum IgE to recombinant Pla a 4, measured by ELISA. The result was confirmed by IgE immunoblot with sera from 22 profilin-sensitized patients. Basophils from 3 of 4 profilin-sensitized patients reacted in a BAT assay with rPla a 4.
Allergenicity reference:PubMed:35158224
Route of allergen exposure:Airway
Date Created:2022-08-22
Last Updated:2022-08-22 18:23:20
Submitter Info:
Name:Jin-Lyu Sun, Ji-Fu Wei
Institution:State Key Laboratory of Complex Severe and Rare Diseases, PUMCH, CAMS; Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research & The Affiliated Cancer Hospital of Nanjing Medical University
City:Beijing, China and Nanjing, China,
Submission Date:2022-08-05


Table of IsoAllergens Click +/- for additional information
Isoallergen and variants GenBank Nucleotide GenBank Protein UniProt PDB
Pla a 4.0101OK323206