WHO/IUIS Allergen Nomenclature Sub-Committee

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Allergen Details:

Allergen name: Pla a 5
Allergen source: Major taxonomic group: Plantae basal Mesangiosperms
Order: Proteales
Species: Platanus acerifolia (London plane tree)
NCBI Taxomony ID: 140101
Biochemical name:Adenosylhomocysteinase (S-adenosyl-L-homocysteine hydrolase, AHCY)
Allergenicity:Twenty-three P. acerifolia-sensitized patients with allergic rhinitis in spring were tested. All has positive SPT and sIgE (measured by ImmunoCAP) to plane tree pollen extract. Of those 12 (52%) had serum IgE to recombinant Pla a 5, measured by ELISA. Natural purified Pla a 5 was tested by IgE immunoblot and yielded a positive signal in 4/7 (57%) tested sera. nPla a 5 was also tested by BAT and activated basophils from all three tested Pla a 5-sensitized patients.
Route of allergen exposure:Airway
Date Created:2022-08-22
Last Updated:2022-08-22 18:24:35
Submitter Info:
Name:Ji-Fu Wei, Jin-Lyu Sun
Institution:Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research & The Affiliated Cancer Hospital of Nanjing Medical University; State Key Laboratory of Complex Severe and Rare Diseases, PUMCH, CAMS
City:Nanjing, China and Beijing, China,
Submission Date:2022-08-05


Table of IsoAllergens Click +/- for additional information
Isoallergen and variants GenBank Nucleotide GenBank Protein UniProt PDB
Pla a 5.0101OK323204UYQ90945