WHO/IUIS Allergen Nomenclature Sub-Committee

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Allergen Details:

Allergen name: Pla a 7
Allergen source: Major taxonomic group: Plantae basal Mesangiosperms
Order: Proteales
Species: Platanus acerifolia (London plane tree)
NCBI Taxomony ID: 140101
Biochemical name:Triosephosphate isomerase (TIM)
Allergenicity:Fifty-eight P. acerifolia-sensitized patients with allergic rhinitis in spring were tested. All has positive SPT and sIgE (measured by ImmunoCAP) to plane tree pollen extract. Of those 24 (41%) had serum IgE to purified natural Pla a 7, measured by ELISA. IgE binding to natural and recombinant Pla a 7 was confirmed by IgE immunoblot with 5 Pla a 7-sensitized sera. nPla a 7 was also tested by BAT and activated basophils from all three tested Pla a 7-sensitized patients.
Route of allergen exposure:Airway
Date Created:2022-08-22
Last Updated:2022-08-22 18:51:11
Submitter Info:
Name:Ji-Fu Wei, Jin-Lyu Sun
Institution:Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research & The Affiliated Cancer Hospital of Nanjing Medical University; State Key Laboratory of Complex Severe and Rare Diseases, PUMCH, CAMS
City:Nanjing, China and Beijing, China,
Submission Date:2022-08-05


Table of IsoAllergens Click +/- for additional information
Isoallergen and variants GenBank Nucleotide GenBank Protein UniProt PDB
Pla a 7.0101OK323203UYQ90944