WHO/IUIS Allergen Nomenclature Sub-Committee

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Allergen Details:

Allergen name: Bac s 1
Allergen source: Major taxonomic group: Bacteria Bacillota
Order: Bacillales
Species: Bacillus subtilis (Hay bacillus)
NCBI Taxomony ID: 86029
Biochemical name:Nattokinase (subtilisin-like serine protease)
Allergenicity:Eigth patients with IgE-mediated food allergy to natto (soybeans fermented with Bacillus subtilis subsp. natto) were tested. All patients had immediate allergic reactions after ingestion of natto as well as positive SPT with natto. Of these patients, 4/8 (50%) had IgE to a 30 kDa protein from natto as well as from an extract from cultured B. subtilis subsp. natto detected by IgE immunoblot. The protein was identified by immunoblot inhibition with commercially available nattokinase and by mass spectrometry. Moreover, all 4 sera reacted to nattokinase in ELISA. Three patients were also tested with nattokinase by SPT and showed a reaction to the protein. Purity of the purchased nattokinase was confirmed by mass spectrometry.
Allergenicity reference:PubMed:36517353
Route of allergen exposure:Food
Date Created:2023-01-11
Last Updated:2023-01-11 17:31:24
Submitter Info:
Name:Masashi Nakamura
Institution:Fujita Health University, Integrative Medical Science for Allergic Disease; Hoyu co. ltd, General Research and Development Institute
City:Nagoya, Japan and Nagakute, Japan,
Submission Date:2022-11-06


Table of IsoAllergens Click +/- for additional information
Isoallergen and variants GenBank Nucleotide GenBank Protein UniProt PDB
Bac s 1.0101KY576911AUR45012A0A2I7MLQ75GL8