ALLERGEN NOMENCLATURE
WHO/IUIS Allergen Nomenclature Sub-Committee

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Allergen Details:

Allergen name: Pap s 2
Allergen source: Major taxonomic group: Plantae basal Mesangiosperms
Order: Ranunculales
Species: Papaver somniferum (Opium poppy)
NCBI Taxomony ID: 3469
Biochemical name:Legumin (11S globulin) seed storage protein
MW(SDS-PAGE):52 kDa (non-reducing), 30 kDa + 20 kDa (reducing)
Allergenicity:Of 36 tested poppy seed-sensitized patients (SPT, sIgE), 10 had allergic symptoms after oral food challenge. Of those, 10 allergic (100%) and 21 tolerant (81%) had IgE to natural Pap s 2 as shown by ELISA. As only the natural allergen was tested, which is a mixture of Pap s 2.0101 and Pap s 2.0201 (as shown by tandem MS), the contributions of the individual isoallergens to IgE binding was not determined.
Allergenicity reference:PubMed:38734371
Route of allergen exposure:Food
Date Created:2023-08-29
Last Updated:2024-05-23 13:18:41
Submitter Info:
Name:Aleksandra Podzhilkova, Merima Bublin
Institution:Department of Pathophysiology and Allergy Research, Medical University of Vienna
City:Vienna, Austria
Email:aleksandra.podzhilkova@muv.ac.at, merima.bublin@muv.ac.at
Submission Date:2023-05-11

Comments

Table of IsoAllergens Click +/- for additional information
Isoallergen and variants GenBank Nucleotide GenBank Protein UniProt PDB
Pap s 2.0101CM010721RZC68862A0A4Y7K963 
Pap s 2.0201CM010715RZC43524A0A4Y7I456