Allergen Details:
| Allergen name: | Pap s 3 |
|---|---|
| Allergen source: |
Major taxonomic group: Plantae basal Mesangiosperms Order: Ranunculales Species: Papaver somniferum (Opium poppy) |
| Biochemical name: | Late embryogenesis abundant protein 5 (LEA-5); small hydrophilic seed protein |
| MW(SDS-PAGE): | 10 kDa |
| Allergenicity: | Of 36 tested poppy seed-sensitized patients (SPT, sIgE), 10 had allergic symptoms after oral food challenge. Of those, 8 allergic (80%) and 17 tolerant (65%) had IgE to natural Pap s 3 as shown by ELISA. As only the natural allergen was tested, which is a mixture of Pap s 3.0101 and Pap s 3.0201 (as shown by tandem MS), the contributions of the individual isoallergens to IgE binding was not determined. |
| Route of allergen exposure: | Food |
| Date Created: | 2023-08-29 |
| Last Updated: | 2023-08-29 18:32:50 |
| Submitter Info: | |
| Name: | Aleksandra Podzhilkova, Merima Bublin |
| Institution: | Department of Pathophysiology and Allergy Research, Medical University of Vienna |
| City: | Vienna, Austria |
| Email: | aleksandra.podzhilkova@muv.ac.at, merima.bublin@muv.ac.at |
| Submission Date: | 2023-05-11 |
Comments
| Isoallergen and variants | GenBank Nucleotide | GenBank Protein | UniProt | PDB |
|---|---|---|---|---|
| Pap s 3.0101 | CM010725 | RZC84488 | A0A4Y7LJ34 | |
| Pap s 3.0201 | CM010725 | RZC84487 | A0A4Y7LHN0 |