WHO/IUIS Allergen Nomenclature Sub-Committee

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Allergen Details:

Allergen name: Can s 7
Allergen source: Major taxonomic group: Plantae Eudikotyledons
Order: Rosales
Species: Cannabis sativa (Indian hemp)
NCBI Taxomony ID: 3483
Biochemical name:Thaumatin-like protein
Allergenicity:Three groups of Cannabis-exposed subjects were tested: 1. 60 Cannabis-allergic patients as confirmed by SPT and specific IgE to Cannabis. 2. 10 pollen-allergic patients without Cannabis allergy, 3. 5 healthy controls. In an ELISA with rCan s 7.0101 (fusion protein of maltose-biding protein with the preprotein of Can s 7.0101), 16/60 (27%) cannabis-allergic patients, 2/10 atopic controls and none of the healthy controls had IgE to rCan s 7. In a passive mast cell activation test with rCan s 7, cells sensitized with 4/5 sera from Can s 7-sensitized cannabis-allergic patients, none of 5 atopic control subjects' sera and 1 of 3 healthy control subjects' sera were activated.
Allergenicity reference:PubMed:37984436
Route of allergen exposure:Airway
Date Created:2023-11-08
Last Updated:2024-03-08 15:35:57
Submitter Info:
Name:Hans-Peter Rihs, Didier G Ebo
Institution:Ruhr University Bochum, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA); Antwerp University Hospital (UZA), Dept. of Immunology, Allergology and Rheumatology
City:Bochum, Germany; Edegem, Belgium;
Submission Date:2023-08-22


Table of IsoAllergens Click +/- for additional information
Isoallergen and variants GenBank Nucleotide GenBank Protein UniProt PDB
Can s 7.0101XM_030646437XP_030502297