Allergen Details
| Allergen name: | Pla a 8 |
|---|---|
| Allergen source: |
Major taxonomic group: Plantae basal Mesangiosperms Order: Proteales Species: Platanus acerifolia (Platanus x hispanica) (London plane tree) NCBI Taxomony ID: 140101 |
| Biochemical name: | Fructose-bisphosphate aldolase |
| MW(SDS-PAGE): | 38 kDa |
| Allergenicity: | Sera from 20 plane tree pollen-allergic patients (allergic rhinitis and/or asthma, sIgE as measured by ImmunoCAP) were tested. Of those, 13 (65%) had IgE to rPla a 8.0101 measured by ELISA. In a Western blot, 5/6 and 4/6 ELISA-positive sera showed IgE binding to the natural and recombinant allergen, respectively. In an indirect BAT, rPla a 8.0101 activated basophils sensitized with sera from 3 ELISA-positive patients. In an inhibition ELISA with a serum pool, natural and recombinant Pla a 8 inhibited IgE binding to P. acerifolia pollen extract by 17%. |
| Route of allergen exposure: | Airway |
| Created: | 2024-07-17 18:55:10 |
| Last Updated: | 2024-07-17 18:58:42 |
| Submitter Info: | |
| Name: | Ji-Fu Wei; Jin-Lyu Sun |
| Institution: | The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research; Chinese Academy of Medical Sciences and Peking Union Medical College |
| City: | Najing, China; Beijing, China |
| Email: | weijifu@hotmail.com; sunjinlv@pumch.cn |
| Submission Date: | 2024-07-13 |
Comments
Table of Isoallergens
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| Isoallergen and variants | GenBank Nucleotide | GenBank Protein | UniProt | PDB |
|---|---|---|---|---|
| Pla a 8.0101 | PP965342 | XCD23615 | A0AAU8BSG0 |