Allergen Details
| Allergen name: | Amb t 18 |
|---|---|
| Allergen source: |
Major taxonomic group: Plantae Eudikotyledons Order: Asterales Species: Ambrosia trifida (Giant ragweed) NCBI Taxomony ID: 4214 |
| Biochemical name: | Triosephosphate isomerase |
| MW(SDS-PAGE): | 26 kDa |
| Allergenicity: | Sera from 37 pollen-allergic patients with allergic symptoms in late summer (rhinitis, conjunctivitis and/or asthma) and sIgE to Ambrosia pollen (ImmunoCAP) were tested. Of those, 13 sera (35%) had IgE to recombinant Amb t 18.0101 produced in E. coli. All 4 tested ELISA-positive sera reacted to the natural and recombinant allergen in an IgE-immunoblot. In an indirect BAT, basophils sensitized with 4 ELISA-positive sera were activated after stimulation with rAmb t 18.0101. In an inhibition ELISA with a pool of ELISA-positive sera, preincubation with rAmb t 18.0101 inhibited IgE binding to Ambrosia trifida pollen extract by 18%. |
| Route of allergen exposure: | Airway |
| Created: | 2024-08-14 12:06:57 |
| Last Updated: | 2024-08-14 12:24:35 |
| Submitter Info: | |
| Name: | Ji-Fu Wei; Jin-Lyu Sun |
| Institution: | Dept. of Pharmacy, Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Inst. of Cancer Research; Dept. of Allergy, State Key Laboratory of Complex Severe and Rare Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College |
| City: | Nanjing, China; Beijing, China |
| Email: | weijifu@hotmail.com; sunjinlv@pumch.cn |
| Submission Date: | 2024-07-25 |
Comments
Table of Isoallergens
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| Isoallergen and variants | GenBank Nucleotide | GenBank Protein | UniProt | PDB |
|---|---|---|---|---|
| Amb t 18.0101 | MW889088 | UVN25793 |