ALLERGEN NOMENCLATURE
WHO/IUIS Allergen Nomenclature Sub-Committee

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Allergen Details

Allergen name: Bro p 3
Allergen source: Major taxonomic group: Plantae Eudikotyledons
Order: Rosales
Species: Broussonetia papyrifera (Paper mulberry)
NCBI Taxomony ID: 172644
Biochemical name:Non-specific lipid transfer protein class 1 (nsLTP1)
MW(SDS-PAGE):12-15 kDa
Allergenicity:In the study by Spillner and Hussain, sera from 81 pollen-allergic patients from Pakistan with symptoms during the paper mulberry flowering season and positive SPT to paper mulberry pollen extract were tested. Of those, 43 sera (53%) had IgE to purified nBro p 3. The allergen also activated basophils of a Bro p 3-sensitized individual. The study by Jiang and Meng recruited pollen-allergic patients from Western China with symptoms during the paper mulberry flowering season as well as positive SPT and sIgE (custom-made ImmunoCAP) to paper mulberry pollen extract. All 38 tested sera had IgE to a 10 kDa allergen in an immunoblot with Bro p extract. In ELISA, 32 (80%) and 31 (78%) of 40 sera had IgE to nBro p 3 and rBro p 3.0101, respectively. In SPT with nBro p 3, 6 of 7 patients were positive.
Allergenicity reference:PubMed:23967755
Route of allergen exposure:Airway
Created:2024-10-08 17:16:43
Last Updated:2024-12-19 18:41:02
Submitter Info:
Name:Edzard Spillner and Abid Hussain; Zihan Jiang and Juan Meng
Institution:Dept. of Biological and Chemical Engineering, Aarhus University and Dept. of Microbiology and Molecular Genetics, University of the Punjab; West China Hospital, Sichuan University
City:Aarhus, Denmark and Lahore, Pakistan; Chengdu, China
Email:e.spillner@bce.au.dk and abihqureshi@gmail.com; jzh_gmail@163.com and mjmelinda@163.com
Submission Date:2024-09-12

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Table of Isoallergens

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Isoallergen and variants GenBank Nucleotide GenBank Protein UniProt PDB
Bro p 3.0101PQ758747 C0HMD1