WHO/IUIS Allergen Nomenclature Sub-Committee

Financial contributions from IUIS, EAACI, and AAAAI

Member Login

Allergen Details:

Allergen name: Bet v 1
Allergen source: Major taxonomic group: Plantae Eudikotyledons
Order: Fagales
Species: Betula verrucosa (Betula pendula) (European white birch)
NCBI Taxomony ID: 3505
Biochemical name:Pathogenesis-related protein, PR-10, Bet v 1 family member
Allergenicity:Bet v 1 is responsible for IgE binding in more than 95% of birch pollen allergic patients
Allergenicity reference:PubMed:6886253
Route of allergen exposure:Airway
Date Created:13-03-2003
Last Updated:2019-07-16 00:30:20
Submitter Info:
Submission Date:


Posted: 19 Jul 2023

At its meeting in February 2013, the IUIS Allergen Nomenclature Sub-Committee decided to update the nomenclature of Bet v 1 isoallergens based on the following principles:
1. The database should contain only Bet v 1 sequences whose expression in pollen has been proved at least on the mRNA level.
2. Similar sequences are grouped as variants of an isoallergen if they show >90% sequence identity.
3. Different variant numbers are assigned only to variants with different protein sequences. Nucleotide sequences differing only be silent mutations are not distinguished by the allergen nomenclature.

As a consequence, the following entries were deleted:
Bet v 1.11-Bet v 1.13 and Bet v 1.15-Bet v 1.23.

The following variants were merged into a single entry:
Bet v 1.0101/0102/0103
Bet v 1.0401/0402 (now Bet v 1.0102)
Bet v 1.0601/0602 (now Bet v 1.0104)
Bet v 1.1401/1402 (now Bet v 1.0204)

The following entries were classified as variants of Bet v 1.01:
Bet v 1.01, Bet v 1.04-Bet v 1.08, Bet v 1.10 and Bet v 1.24-Bet v 1.30.

The following entries were classified as variants of Bet v 1.02:
Bet v 1.02, Bet v 1.03, Bet v 1.09 and Bet v 1.14.

Posted: 13 Nov 2016

See PLOS One Spiric et al., 2015, open access journal. Series of 9 Bet v 1 sequences added at request of Andreas Reuter, PEI, 27 Aug 2015, from 2D Gel and LC-MSMS proteomics of pollen extract. the 9 sequences listed here, match previous cDNA clones by others.
Bet v 1.0115
Bet v 1.0116
Bet v 1.0117
Bet v 1.0118
Bet v 1.0119
Bet v 1.0205
Bet v 1.0206
Bet v 1.0207
Bet v 1.0301
Proof of expression in pollen and high sequence identity to other Bet v 1 isoforms (1 at 75%, the remainder at 85-99% identity).

Table of IsoAllergens Click +/- for additional information
Isoallergen and variants GenBank Nucleotide GenBank Protein UniProt PDB
Bet v 1.0101X15877 Z80098 Z80099CAA33887P154944A88
Bet v 1.0102X77266 X77270CAA54482P43177 
Bet v 1.0103X77267CAA54483P43178 
Bet v 1.0104X77268 X77274CAA54484P43179 
Bet v 1.0105X77269CAA54485P43180 
Bet v 1.0106X77271CAA54487P431834A8U
Bet v 1.0107X77273CAA54489P431851FM4
Bet v 1.0108Z80100CAB02155Q96365 
Bet v 1.0109Z80101CAB02156Q96366 
Bet v 1.0110Z80102CAB02157Q96367 
Bet v 1.0111Z80103CAB02158Q96368 
Bet v 1.0112Z80104CAB02159P15494 (variant F63L)1BV1 1BTV
Bet v 1.0113Z80105CAB02160Q96370 
Bet v 1.0114Z80106CAB02161Q96371 
Bet v 1.0115Z72438.1CAA96547Q39431 
Bet v 1.0116AJ001555.1CAA04827.1O23748 
Bet v 1.0117AJ006908.1CAA07323.1Q9SCI0 
Bet v 1.0118AJ006914.1CAA07329.1Q9SCH6 
Bet v 1.0119DQ296603.1ABC41615.1Q0QLS9 
Bet v 1.0201X77200CAA54421P45431 
Bet v 1.0202X77265CAA54481P43176 
Bet v 1.0203X77272CAA54488P43184 
Bet v 1.0204X81972 X82028CAA57550P43186 
Bet v 1.0205Z72431.1CAA96540.1Q39427 
Bet v 1.0206AJ001556.1CAA04828.1O23749 
Bet v 1.0207EU526193.1ACF75030.1Q0QLV2 
Bet v 1.0301X77601.1CAA54696.1Q39415