WHO/IUIS Allergen Nomenclature Sub-Committee

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Allergen Details:

Allergen name: Chi t 1
Allergen source: Major taxonomic group: Animalia Arthropoda
Order: Diptera
Species: Chironomus thummi thummi (Midge)
NCBI Taxomony ID: 7155
Obsolete name:Chi t I
Biochemical name:Hemoglobin, component III/IV
Allergenicity:Of 86 subjects with IgE against C.thummi thummi larvae, 76 had IgE against Chi t I, which comprises 12 homologous hemoglobins (Chi t 1-9). 56 of these 76 people were symptomatic. Chi t I induced histamine release in basophils of all 20 patients tested, and acute rhinitis and/or asthmatic reactions in all 25 patients tested in inhalation challenge test. - Of 15 patients allergic to C.thummi Thummi all had IgE against Chi t 1.01. 13 patients reacted with peptide 80-100 in ELISA: medline 2108351 - Of 15 C.thummi thummi-sensitized patients, all showed IgE binding to Chi t 1.02 in ELISA: medline 21083518.
Allergenicity reference:PubMed:1701849
Route of allergen exposure:Airway
Date Created:20-05-2003
Last Updated:2019-07-31 07:36:41
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Table of IsoAllergens Click +/- for additional information
Isoallergen and variants GenBank Nucleotide GenBank Protein UniProt PDB
Chi t 1.0101M17600AAA28249P022291ECA
Chi t 1.0201X00920CAA25438P02230