WHO/IUIS Allergen Nomenclature Sub-Committee

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Allergen Details:

Allergen name: Hev b 2
Allergen source: Major taxonomic group: Plantae Eudikotyledons
Order: Malpighiales
Species: Hevea brasiliensis (Para rubber tree (latex))
NCBI Taxomony ID: 3981
Biochemical name:beta-1,3-glucanase; glucan endo-1,3-beta-glucosidase, basic vacuolar isoform
MW(SDS-PAGE):35, 36.5 and 38 kDa
Allergenicity:Pubmed:9525455: Of 15 latex allergic patients, 6 (40%) reacted with purified nHev b 2 in immunoblot and ELISA. - PubMed:12372996: All sera of 34 latex sensitized patients also sensitized to nHev b 2 bound to three separated isoforms in ELISA. In immunoblot, only the glycosylated isoforms I and II, but not the non-glycosylated isoform III were recognized. In SPT, 3-4 of 7 patients reacted with the isoforms.
Allergenicity reference:PubMed:9525455PubMed:12372996
Route of allergen exposure:Contact
Date Created:03-07-2003
Last Updated:2019-07-17 18:36:27
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Table of IsoAllergens Click +/- for additional information
Isoallergen and variants GenBank Nucleotide GenBank Protein UniProt PDB
Hev b 2.0101U22147AAA87456P52407