WHO/IUIS Allergen Nomenclature Sub-Committee

Financial contributions from IUIS, EAACI, and AAAAI

Member Login

Allergen Details:

Allergen name: Hev b 4
Allergen source: Major taxonomic group: Plantae Eudikotyledons
Order: Malpighiales
Species: Hevea brasiliensis (Para rubber tree (latex))
NCBI Taxomony ID: 3981
Biochemical name:Lecithinase homologue; GDSL lipase/esterase family member
MW(SDS-PAGE):53-55 kDa
Allergenicity:- Pubmed:10691894: nHev b 4 bound IgE from 20 of 31 (65%) latex allergic health care workers and 10 of 13 (77%) patients with spina bifida in ELISA. - Pubmed:12642845: Of 62 health care workers who had experienced immediate skin reactions to NRL gloves, 39% had positive SPT response to purified nHev b 4. - Pubmed:16297147: Chemical deglycosylation of nHev b 4 abolished IgE binding of 3 latex allergic patients sera.
Allergenicity reference:PubMed:10691894PubMed:12642845PubMed:16297147
Route of allergen exposure:Contact
Date Created:03-07-2003
Last Updated:2019-07-17 18:36:53
Submitter Info:
Submission Date:


Table of IsoAllergens Click +/- for additional information
Isoallergen and variants GenBank Nucleotide GenBank Protein UniProt PDB
Hev b 4.0101AY437086AAR98518Q6T4P0