Allergen Details:
| Allergen name: | Len c 2 |
|---|---|
| Allergen source: |
Major taxonomic group: Plantae Eudikotyledons Order: Fabales Species: Lens culinaris (Lentil) |
| Biochemical name: | Seed-specific biotinylated protein |
| MW(SDS-PAGE): | 66 kDa |
| Allergenicity: | Of 22 lentil-allergic patients tested, 9 (41%) showed IgE binding to purified Len c 2 on immunoblot. IgE binding to Lentil extract was inhibited up to 45% by purified Len c 2 in CAP inhibition assay. |
| Allergenicity reference: | PubMed:11080720 |
| Route of allergen exposure: | Food |
| Date Created: | 26-06-2003 |
| Last Updated: | 2019-08-29 02:18:26 |
| Submitter Info: | |
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Comments
| Isoallergen and variants | GenBank Nucleotide | GenBank Protein | UniProt | PDB |
|---|---|---|---|---|
| Len c 2.0101 |
No record of the submission, but based on the reference of Sanchez-Monge...Gabriel Salcedo, the peptide list and description, it is from their 2000 paper in JACI, v106:955-961. Note that they have only a few peptides from protease digested and semi-purified fragments that have high identity match to a pea biotinylated seed protein. Only pooled serum immunoblot is shown although claimed that 9 of 22 lentil allergic subjects bound to this protein, without clear description of method or results.