Allergen Details
| Allergen name: | Asc l 13 |
|---|---|
| Allergen source: |
Major taxonomic group: Animalia Nematoda Order: Ascaridida Species: Ascaris lumbricoides (Common roundworm) NCBI Taxomony ID: 6252 |
| Biochemical name: | Glutathione S-transferase (GST) |
| MW(SDS-PAGE): | 23 kDa |
| Allergenicity: | 26 (90%) of 29 patients exposed to A. lumbricoides with positive CAP to A. lumbricoides showed IgE binding to purified natural Asc l 13 in ELISA. Of 12 patients tested by SPT with nAsc l 13, 5 (42%) reacted. The identity of the natural purified Asc l 13 was established by sequencing 73% of the protein by MS/MS. |
| Allergenicity reference: | PubMed:24223794 |
| Route of allergen exposure: | Food |
| Created: | 2014-09-08 12:00:00 |
| Last Updated: | 2019-07-11 22:58:02 |
| Submitter Info: | |
| Name: | Luis Caraballo |
| Institution: | University of Cartagena, Institute for Immunological Research |
| City: | Cartagena, Colombia |
| Email: | lcaraballog@unicartagena.edu.co |
| Submission Date: | 2013-05-18 |
Comments
The glutathione transferase of Ascaris lumbricoides and Ascaris suum are nearly identical. Serum IgE from a number of subjects in Cartagena showed IgE binding to both in the published article in PLOS ONE.
Table of Isoallergens
Click on the arrows to show the details of individual isoallergens, click on +/- to show/hide the details of all isoallergens.
| Isoallergen and variants | GenBank Nucleotide | GenBank Protein | UniProt | PDB |
|---|---|---|---|---|
| Asc l 13.0101w | BU585392 | P46436 | P46436 (Ascaris suum GST) |
The 'w' at the end of the allergen isoform designation signifies that an authentic and complete cDNA sequence encoding this allergen is not available (see 'Sequence features" of Asc l 13.0101w below.