Allergen Details:
| Allergen name: | Asc l 13 |
|---|---|
| Allergen source: |
Major taxonomic group: Animalia Nematoda Order: Ascaridida Species: Ascaris lumbricoides (Common roundworm) |
| Biochemical name: | Glutathione S-transferase (GST) |
| MW(SDS-PAGE): | 23 kDa |
| Allergenicity: | 26 (90%) of 29 patients exposed to A. lumbricoides with positive CAP to A. lumbricoides showed IgE binding to purified natural Asc l 13 in ELISA. Of 12 patients tested by SPT with nAsc l 13, 5 (42%) reacted. The identity of the natural purified Asc l 13 was established by sequencing 73% of the protein by MS/MS. |
| Allergenicity reference: | PubMed:24223794 |
| Route of allergen exposure: | Food |
| Date Created: | 16-07-2013 |
| Last Updated: | 2019-07-11 22:58:02 |
| Submitter Info: | |
| Name: | Luis Caraballo |
| Institution: | University of Cartagena, Institute for Immunological Research |
| City: | Cartagena, Colombia |
| Email: | lcaraballog@unicartagena.edu.co |
| Submission Date: | 2013-05-18 |
Comments
The glutathione transferase of Ascaris lumbricoides and Ascaris suum are nearly identical. Serum IgE from a number of subjects in Cartagena showed IgE binding to both in the published article in PLOS ONE.
| Isoallergen and variants | GenBank Nucleotide | GenBank Protein | UniProt | PDB |
|---|---|---|---|---|
| Asc l 13.0101w | BU585392 | P46436 | P46436 (Ascaris suum GST) |
The 'w' at the end of the allergen isoform designation signifies that an authentic and complete cDNA sequence encoding this allergen is not available (see 'Sequence features" of Asc l 13.0101w below.