WHO/IUIS Allergen Nomenclature Sub-Committee

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Allergen Details:

Allergen name: Act d 13
Allergen source: Major taxonomic group: Plantae Eudikotyledons
Order: Ericales
Species: Actinidia deliciosa (Green kiwi fruit)
NCBI Taxomony ID: 3627
Biochemical name:2S albumin
MW(SDS-PAGE):11,359,6 Da (mass spectrometry), 4 peptide seqeunces (C0HJG, to be released upon publication)
Allergenicity:Sera from 10 of 55 kiwifruit allergic individuals had IgE that reacted with the purified natural Act d 13 in immunobolots and ELISA. A basophil activation test of 1 patient with the purified nAct d 13 was positive. A SPT of 1 patient with the purified nAct d 13 was positive.
Allergenicity reference:PubMed:25041438PubMed:24990823
Route of allergen exposure:Food
Date Created:28-11-2013
Last Updated:2019-06-28 06:47:08
Submitter Info:
Name:Oscar Palomares
Institution:School of Chemistry, Complutense University of Madrid, Department of Biochemistry and Molecular Biology
City:Madrid, Spain
Submission Date:2013-11-28


Posted: 02 Aug 2018

There is no clear complete sequence for Act d 13. Sirvent S, et al., 2014 in a note in JACI show purification and biochemical characterization, but only four peptide sequences (by MS) that show partial sequence identities to a mustard 2S (Sin a 1, uniprot P15322) and to Brassica rapa or napus. The paper by Sirvent, Canto et al., 2014 Allergy) does not show sequence identity or refer to sequence. Neither does the paper by Nilsson et al., Ped Allergy and Immunology 2015. Unless a sequence can be determined and published that clearly represents this 2S albumin from kiwi, the identity of the allergen is not certain. However a search of protein databases shows an 8 amino acid segment "gpqqqhrl" as entry Accession C0HJG0. That is not enough for specific identity. REG 1 Aug 2018

Table of IsoAllergens Click +/- for additional information
Isoallergen and variants GenBank Nucleotide GenBank Protein UniProt PDB