Allergen Details:
| Allergen name: | Der f 29 |
|---|---|
| Allergen source: |
Major taxonomic group: Animalia Arthropoda Order: Sarcoptiformes Species: Dermatophagoides farinae (American house dust mite) |
| Biochemical name: | Peptidyl-prolyl cis-trans isomerase (cyclophilin) |
| MW(SDS-PAGE): | 15 kDa |
| Allergenicity: | 35 of 41 HDM sensitized subjects had IgE binding to Der f 29, cyclophilin, by immunoblot, 9 shown in publication. The nine were positive by ELISA and activated CCR3 >20% in BAT. In addition, 7 or 10 HDM allergic subjects were SPT + to rDer f 29. |
| Allergenicity reference: | PubMed:23481662 |
| Route of allergen exposure: | Airway |
| Date Created: | 04-11-2014 |
| Last Updated: | 2019-08-15 20:27:50 |
| Submitter Info: | |
| Name: | Su An |
| Institution: | Kunming Institute of Zoology, Chinese Academy of Sciences |
| City: | Kunming, China |
| Email: | aslxj@mail.ustc.edu.cn |
| Submission Date: | 2013-10-17 |
Comments
NOTE: NCBI and UniProt show "Der f 29" as profilin, but that entry (Accession AIO08866.1) was not submitted to IUIS and is illegitimate.
| Isoallergen and variants | GenBank Nucleotide | GenBank Protein | UniProt | PDB |
|---|---|---|---|---|
| Der f 29.0101 | AY283280.1 | AAP35065 | A1KXG2 |
NOTE: Zhiling Liang; Jianli Lin; Zhigang Liu; Pingchang Yang; Yulan Wu; Xiaoyu Liu submitted an identical protein sequence to IUIS on 2014-10-17 before we posted the An Su sequence. Liang et al., state that their protein was 19 kDa, nucleotide accession KM010000, but called it Der f 26. However due to prior submission Su An submission takes precedent. For allergenicity Liang et al., stated 9 of 52 subjects were SPT positive with recombinant, and 5 of 5 were positive by immunoblot and ELISA testing IgE.