WHO/IUIS Allergen Nomenclature Sub-Committee

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Allergen Details:

Allergen name: Per a 11
Allergen source: Major taxonomic group: Animalia Arthropoda
Order: Blattodea
Species: Periplaneta americana (American cockroach)
NCBI Taxomony ID: 6978
Biochemical name:alpha-amylase
Allergenicity:Sera from 39 of 40 (83%) patients reacted to Per a 11 on immunoblots. ELISA inhibition of serum IgE reactivity to the cockroach midgut extract (CME) using purified Per a 11 was significant (60%). Twelve of 15 (80%) cockroach-allergic patients had positive SPT reactions to Per a 11. In comparison with healthy control, Per a 11 at 1.0 g/ml induced approximately up to 5.8-fold increase in the number of CD63 and CCR3 double-positive cells following incubating it with PBMC from patients with cockroach allergy
Allergenicity reference:PubMed:26361742
Route of allergen exposure:Airway
Date Created:02-06-2015
Last Updated:2020-03-24 19:42:23
Submitter Info:
Name:Su An
Institution:Kunming Institute of Zoology, Chinese Academy of Sciences
City:Kunming, China
Submission Date:2015-05-05


Table of IsoAllergens Click +/- for additional information
Isoallergen and variants GenBank Nucleotide GenBank Protein UniProt PDB
Per a 11.0101KR019685AKH04310